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深圳湾实验室化学生物学研究所2020年招聘信息

研究所简介

践行"健康中国"利来棋牌_[官网入口]战略,针对中国市场打造生命科学与生物医药产业链,推动粤港澳大湾区创新基地建设。借助斯克瑞普斯研究所"从实验到临床"的成功模式,在深圳创办创新药物研发与推广平台。

筛选系统及化合物库建设:建立全自动超高通量筛选系统(uHTS),具有苗头分子分拣和化合物管理功能;建立一系列独有的,定制的大型的化合物库,总的化合物数量在一百万个左右;建立基于CalibrReFrame库,重新建立一个包含15000多种化合物的药物再开发化合物库。

实验平台建设:体外生物学实验室;药物化学实验室;蛋白质治疗实验室;药理学实验室。

Tenure-track assistant professor positions at Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute, Shenzhen, China

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute is recruiting globally to fill multiple tenure-track assistant professor positions in Shenzhen, China.  The area of research is open but should fit within the broad scope of chemical and biological sciences, with emphasis on the interface between them in the context of disease and drug discovery.

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute, Shenzhen, China, is a newly established partnership  between Scripps Research and Shenzhen Bay Laboratory (SZBL) (see reports at:

http://www.scripps.edu/news-and-events/press-room/2019/20191127-szbl-collaboration.html; and http://www.szbl.ac.cn/news_detail_en.aspx?detail=19746&parm=948).  Scripps Research — one of the world's largest, private, non-profit biomedical research organizations — is ranked the most influential institution in the world for its impact on innovation.  SZBL  strives to become a hub for world-class research at the forefront of health science and innovation.  The joint institute combines the expertise of both institutions to pursue basic and translational research at the intersection of biology and chemistry.

Qualified candidates should have a Ph.D. or M.D. degree, with postdoctoral training or industrial experience, and an outstanding record of research that demonstrates originality at addressing significant questions.  Successful candidates are expected to establish an active research group and pursue a program of high-quality research that will result in breakthrough discoveries or technology advancements.

Scripps Research | Shenzhen Bay Laboratory Chemical Biology Institute welcomes applicants of all nationalities and will provide an internationally competitive start-up package and salary.  Successful candidates will also receive a joint appointment from PKU Shenzhen Graduate School.  The initial appointment will be 5 years and renewal is based on reviews by an international committee.

Applicants should submit (1) curriculum vitae, (2) statement of research interests, (3) future research plans, and (4) three confidential letters of recommendation to email: wshen@scripps.edu or zyang@pku.edu.cn.  Applications will be reviewed on a rolling basis until all positions are filled.

Directors/Principal Investigators for Disease Biology (Job Code: SZBL 1001), Medicinal Chemistry (Job Code: SZBL 1002), in vivo Pharmacology (Job Code: SZBL 1003), Peptide, Protein and/or Antibody engineering (Job Code: SZBL 1004) and program management (Job Code: SZBL 1005)

About Scripps Research/Shenzhen Bay Laboratory Chemical Biology Institute; Shenzhen, China

Scripps Research is joining forces with Shenzhen Bay Laboratory to establish a joint Chemical Biology Institute (see announcements at: http://www.scripps.edu/news-and-events/press-room/2019/20191127-szbl-collaboration.html and http://www.szbl.ac.cn/news_detail_en.aspx?detail=19746&parm=948). Within this institute, the Division of Translational Research will consist of preclinical drug discovery and early drug development expertise and capabilities for small molecules, peptides/proteins and antibodies. Our state of the art facilities will include high throughput screening (HTS) and diverse small molecule libraries (1 million), with capabilities for medicinal chemistry optimization, peptide/protein and antibody engineering, PK and in vivo efficacy studies. Researchers will work closely with scientists from Calibr at Scripps Research, as well as collaborators within the Shenzhen Bay Laboratory and other institutions, to translate biomedical basic discoveries into innovative new drugs that will impact the major diseases of unmet need.

JOB SUMMARY

We are seeking talented PI/Director level managers in Disease Biology, Medicinal Chemistry, in vivo Pharmacology, Peptide, Protein and Antibody engineering to lead a dynamic, interdisciplinary team of research associates and post-doctoral scientists as well as coordinate CRO efforts to develop new therapeutic approaches to unmet medical needs through early stage translational research. Partnerships with various for-profit and non-profit organizations will be a key component of the workflow, and work will be published in high-impact, peer-reviewed journals.

RESPONSIBILITIES AND DUTIES

     Responsible for developing and leading key research projects in alignment with the Institute’s mission and goals

     Provides successful project and team leadership of both in-house and/or CRO resources

     Uses in depth literature search skills to generate new project proposals and maintain a pipeline for successful pre-clinical candidates

     Works with senior management to identify and develop new relevant and viable research projects and directions

     Authors research reports, generates scientific presentations and manages research timelines

DECISION MAKING

Independently designs, executes, interprets and reports results of work.  Additionally, oversees consistency and accuracy of results and documentation. Exercise judgment to make decisions and solve problems independently.  Escalates issues and risks that significantly affect timelines.

COMMUNICATION

Strong communication skills that enable leadership of and coordination with colleagues, CRO personnel, and management teams to direct projects effectively. 

SCOPE AND COMPLEXITY

Principal Investigator is independently responsible for leading overall strategic as well as day-to-day research activities. Works collaboratively with teams in coordination of group goals.  Works on extremely complex problems and requires the ability to adapt quickly and evaluate intangible variables.  Exercise judgement in developing methods, techniques and criteria for obtaining results.

SUPERVISION OF OTHERS

Manages scientific staff related to applicable projects.  May have oversight of CRO relationship working to ensure goals and timelines are met accordingly. 

POSITION REQUIREMENTS

     Candidates must have Ph.D. in a pertinent scientific field with 7+ years of related scientific experience and 3+ years of supervisory experience

     Strong bench skills and a proven track record in area of specified science

     Demonstration of highly successful project execution across disease areas using in-house and/or CRO resources leading to preclinical candidates for further clinical development

     Demonstrated skills in managing, mentoring and supervising team members; commitment to diversity and inclusion

     Highly motivated, creative, and devoted to project goals

     Impeccable attention to detail, and excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation

     Able to contribute in a meaningful way to scientific discourse

     Prior involvement in drug discovery and early development in pharma settings are highly preferred

     Highly motivated, creative, and able to maintain excellent documentation of their work including writing grant applications and third-party partnership plans

     Able to collaborate proficiently and communicate effectively with colleagues, project management and senior leadership

Applicants should submit your curriculum vitae, cover letter and reference letters to email: wshen@scripps.edu.  Applications will be reviewed on a rolling basis until all positions are filled.

The above statements describe the level of work performed and expected in general terms.  The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of the Institute, with or without notice.

HTS engineer

Position Overview:

Automation Engineer/head of High Throughput Screening

Shenzhen Bay Laboratory is seeking a talented Automation Engineer/Head to lead the Automation and High Throughput Screening group.  The individual would be responsible for running, managing and maintaining laboratory automation as well as biochemical and cell-based assay development for HTS.  A successful candidate will have experience in lab automation, screening and assay development. 

Specialization in one or more the following is highly desirable: cell-based and biochemical assay development, High Content Imaging and Flow Cytometry or programming in Java, C# or related languages.  We are looking for someone who truly enjoys working with technology, so candidates with recreational interest in programming, auto repair, Arduino devices, etc. may be an especially good fit.

Essential Duties and Responsibilities:

     Operate, maintain and troubleshoot uHTS System

     Assay Development, Optimization and miniaturization

     Troubleshooting screening issues related to both automation and assay conditions

     Continual improvement of technologies through innovation

     Data analysis of high throughput screens.

Qualifications and Experience:

Requirements

     MS or PhD degree in engineering, biology or a relevant field with 2-5 years of experience in Lab Automation and Screening. 

     Assay Development of Biochemical and cell-based assays

     Experience running and troubleshooting Lab Automation including but not limited to liquid handling, acoustic dispensers, multi-mode readers, compound transfer devices, etc.

     Ability to troubleshoot equipment problems and perform quality testing.

     Working with teams to transition an assay from the bench to a high throughput screen.

     Able to collaborate proficiently and communicate effectively with colleagues and management

     High level of self-motivation.

Experience in one or more of the following is highly desirable

     Programming in Java, C#, JavaScript and other languages

     Programming and operation of the Labcyte Echo and Access system, Agilent Bravo, Tecan Freedom Evo, BMG Pherastar multi-reader, larger multi station-based systems such as HighRes and GNF Systems.

     High Content Imaging and or Flow Cytometry

     Cell based and biochemical assay development

     Statistical Analysis and/or Design of Experiment

Compensation and Salary: $100k to $150k/y

Purpose of the initial working period at Calibr, Scripps Research:

     Learn the cutting-edge technologies in uHTS systems

     Help design the state of the art ultra HTS systems that fit the best need of the new institute in Shenzhen

     Work with the vendors from various suppliers to assemble and integrate the uHTS system

     Build-up first-hand experience in daily operation and maintenance, data acquisition and processing, and troubleshooting and service.

     Facilitate alignment and future collaboration with Scripps Research.

Contact :

Please send the CV by email attachment to the Dr. Shen:wshen@scripps.edu 

Email subject: the title of the position for which you are applying.

For more details on SZBL and our research, please visit our website: www.szbl.ac.cn

Email content: please include your contact information, name, telephone number, and any dates on which you would be unavailable for an interview. Upon request, applications will be considered confidentially.

Compound Management Lead Candidate JO

The Position

This position will require the successful candidate to start a Compound Management group from the ground up. A strong background in Compound management is required. He/she will establish a workflow for sample request and fulfillment, select appropriate lab automation and software, receive requests for samples, track, coordinate, and perform order fulfillment and distribution of both solids, solutions, and plates to scientists.

Education and Experience:

     Bachelor's degree in Engineering, Biochemistry, Chemistry or related field

     5+ years experience the in a compound management, high throughput screening and/or lab automation

     A proven track record managing a group.

     Experience with liquid handling equipment and other laboratory automation technology systems. Experience with the span-8 liquid handlers (e.g. Tecan Evo, Hamilton Star), acoustic dispensers, plate transfer devices and related experience.

     Proven track record of evaluating, selection, implementation of lab equipment and software  and the generation of SOPs.

     Experience with LIMS and inventory management software.

The activities of the Compound Management Group include, but are not limited to, those shown below. Applicants should have experience in all the following:

     Manual handling of all incoming compounds; including powder weighing, dissolution, and plating.

     Handle logistical aspects of compound management; including sample inventory tracking and storage and ensure accurate record keeping.

     Responsible for uploading data to compound registry, curation of registry, and managing data workflow.

     Prioritize and communicate timelines; provide progress updates to the group.

     Weighing and preparing compounds and solutions

     Arraying compounds from vials to microtiter plates

     Re-array compound plates

     Maintaining and tracking compound library database

     Provide support for sample receiving/sorting services, plate generation, screening, inventory maintaining and QC support using various liquid handling instruments for Compound Management.

     Provide liquid handling performance monitoring services and other laboratory equipment maintenance per customer SOPs.

     Keep accurate data entry of all activities in Tracking Database.

     Provide operational flexibility by cross-training across all job functions with other team members.

     Carefully follow customer SOP’s, orders, and schedules.

Proposed salary and benefit: 70k-100k/y

 

 

Purpose of the initial working period (6 months) at Calibr, Scripps Research:

     Help assemble the key compound libraries for ultra HTS that fit the best need of the new institute in Shenzhen

     Get trained with the appropriate lab automation and software

     Familiarize with the workflow of sample requests and fulfillment, track, coordinate, and perform order fulfillment and distribution of both solids, solutions, and plates to scientists and CRO vendors

     Build-up first-hand experience in daily operation and maintenance, library maintenance and replenishment and troubleshooting and service.

 

Contact:

 

Please send the CV by email attachment to the Dr. Shen: wshen@scripps.edu 

Email subject: the title of the position for which you are applying.

For more details on SZBL and our research, please visit our website: www.szbl.ac.cn

Email content: please include your contact information, name, telephone number, and any dates on which you would be unavailable for an interview. Upon request, applications will be considered confidentially.

 

蛋白组学质谱应用工程师

一、岗位工作内容

1、负责蛋白质组学样品制备(包括各种样品前处理方法和酶解等)、液相色谱串联质谱分析,以及质谱相关操作方法的优化开发;

2、负责基于质谱的蛋白组学数据处理与分析,包括数据库搜索等;

3、负责培训并指导实验人员完成相关实验操作;

4、负责蛋白组学质谱的日常维护保养;

5、其它岗位相关工作。

二、应聘条件

1、硕士及以上学历;

2、分子生物学、生物化学、分析化学、细胞生物学等专业,有蛋白质组学相关项目研究背景;

3、对蛋白质组学有深入了解和研究,熟练掌握蛋白质组学相关的理论、方法和应用,熟悉蛋白质组学相关数据库及相关分析软件,熟悉蛋白质组学数据的统计与分析;

4、良好的英语阅读及表达能力,有较强学习能力、沟通能力及团队协作精神。

三、工作条件和待遇

1、单位提供具有竞争力的薪资待遇,具体薪资和职位面议;

2、符合条件的申请人可申请深圳市相关配套待遇(如孔雀计划等),深圳湾实验室可协助进行申请。

四、应聘者请提供以下材料

1、个人简历;

2、《深圳湾实验室职位申请表》(见附件)

五、应聘程序

1.    提交简历等材料:应聘者请将应聘材料发送至招聘专用邮箱hr_office@szbl.ac.cn,请在邮件主题中标明“深圳湾实验室+岗位名称+姓名+利来棋牌_[官网入口]高校人才网”。招聘小组在收到简历后,将通过电话以及邮件发送面试邀请。

2.    招聘考核及考核结果发布:招聘考核分为资格审查、专家面试等环节。面试通过后即发布录用通知。

六、联系人

联系人:王老师;电话:0755-26653579

Emailhr_office@szbl.ac.cn

附件:深圳湾实验室职位申请表

 

 

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